Considerations for Practice

The wide range of iron deficiency aetiologies from across the therapeutic spectrum as well as the most up-to-date advances in treatment, are highlighted in a comprehensive review by expert in the field and Iron Therapy Editorial Board member, Professor Michael Auerbach. The authors describe the far-reaching impact of iron deficiency on patients’ well-being and clinical outcomes, and further present intravenous iron therapy as an effective treatment alternative to oral iron.

20Jeong et al recently reported the results of a retrospective observational study of 527 patients undergoing gastrectomy for gastric carcinoma. Patients with acute postoperative anaemia (haemoglobin <10 g/dL) received intravenous iron sucrose. Patients with preexisting, preoperative anaemia were excluded. A dose of 300 mg was administered every other day until reaching the total target amount, calculated as:

(body weight x [target haemoglobin – current haemoglobin] x 0.24) + 500 mg

Most physicians and health managers assume that allogeneic blood transfusion (ABT) is always life-saving, cheap, free of risk, and cost–effective. This is believed despite questionable efficacy and increasingly reported adverse events in patients who undergo ABT. In contrast, alternatives to allogeneic blood transfusion (AABT) are frequently considered less efficacious and non cost–effective when compared with conventional ABT.

Stefan Anker is Professor of cardiology and cachexia research at Charité Universitätsmedizin Berlin, Germany. He is active in biomarker, anaemia, metabolic, immunological and nutrition research, with a particular focus on developing new therapies for heart failure and for cachexia. Professor Anker currently serves on the Board of the European Heart Failure Association (HFA) and is President of the HFA (2012–2014).

Reference ranges of iron status parameters established for adults are not suitable to define iron status in preterm infants, a new article indicates. The study authors state that iron therapy in preterm infants should be individually adjusted based on iron status parameters from cord blood concentration ranges to enable optimal growth and development.

Traditionally, diabetes has been linked with iron overload and haemochromatosis. Our study, which was published recently in Diabetes Care, demonstrates that iron deficiency is prevalent in patients with stable coronary artery disease and type 2 diabetes, and that it may be linked with a poor prognosis for this patient group.


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