Iron deficiency

Hepcidin may differentiate between types of anaemia, which may lead to varied therapeutic strategies, according to new research. Authors suggest that hepcidin may be more effective as a diagnostic marker of anaemia in cancer patients than serum iron, total iron-binding capacity (TIBC), or transferrin saturation (TSAT). They state that hepcidin could be used as a serological marker in the differential diagnosis of tumour-related anaemia of chronic disease (ACD) and iron deficiency anaemia.

Iron sucrose is a frequently used intravenous iron compound for the treatment of iron deficiency and iron deficiency anemia in a broad range of therapeutic areas, including in patients with conditions such as chronic kidney disease, inflammatory bowel disease, pregnancy (second and third trimester), postpartum period, heavy menstrual bleeding and cancer.

New data reveals an increased risk of iron deficiency and iron deficiency anaemia in premenopausal women who are of Asian ethnicity, regularly donate blood and who have a previous history of iron deficiency. The analysis also indicates that dietary patterns have a smaller, but still substantial, effect on the risk of developing the condition.

Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by largely nocturnal, rest-induced, distressing urges to move the legs1.  Insomnia, interference with relationships and cramps are common, contributing to a decreased quality of life2,3. Iron deficiency is commonly associated with RLS2,3 and there are approximately three million patients in the USA alone with both conditions4. The role of intravenous iron as a primary therapy for iron deficient patients with RLS has become an area of major clinical research5

Iron deficiency is an important pathogenic factor affecting the severity and progression of chronic heart failure. Until now, iron deficiency diagnosis was based on the assessment of transferrin saturation and serum ferritin. Unfortunately, these standard measures of iron status are unreliable in the acute clinical settings (such as in acute heart failure)1.


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