Nephrology

Preoperative iron deficiency is associated with low haemoglobin levels and a high rate of intraoperative blood transfusion, according to a new study. The authors suggest that pretransplant iron deficiency is a prognostic factor for intraoperative transfusion, which may have important implications for future transfusion practices in liver transplant recipients.

Single-dose ferric carboxymaltose has similar safety and tolerability compared with current treatments for iron deficiency anaemia in patients with chronic kidney disease (CKD), new data shows. The treatment could be suitable for outpatient use, potentially decreasing the need for patient clinic visits and venipuncture.

High dose intravenous ferric carboxymaltose does not alter levels of inflammatory and endothelial markers in patients with pre-dialysis chronic renal failure and iron deficiency anaemia, according to a new report. The study provides initial evidence addressing concerns regarding the pro-inflammatory properties of intravenous iron.

The European Renal Best Practice (ERBP) group has published a statement in response to some of the recommendations laid out in the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for anaemia management in chronic kidney disease1. The group felt that some of the KDIGO recommendations were ‘soft’ and that the global guidelines needed to be adapted for implementation at a European level.

Reticulocyte haemoglobin content can aid diagnosis of functional iron deficiency, a new study shows. Screening the concentration of reticulocytes in the blood can help to discriminate between functional iron deficiency and iron deficiency caused by chronic renal failure (CRF) or anaemia of chronic disease (ACD). The test allows detection of iron deficiency at an earlier stage than current tests allow, potentially improving prognosis.

Using intravenous iron to achieve haemoglobin targets in patients with chronic kidney disease (CKD) on haemodialysis is more cost-effective than oral iron, a new study indicates. The research also suggests that intravenous iron may better improve survival and quality of life, implying that this treatment approach should be adopted for this patient population.

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