Treatment

Professor Michael Bohm at ESC 2012
Professor John Cleland at ESC 2012
Professor Alain Cohen-Solal at ESC 2012
Professor Dirk van Veldhuisen at ESC 2012

In 2012, the European Society of Cardiology (ESC) published updates to their Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure. For the first time, the guidelines consider iron deficiency as a significant co-morbidity in its own right, independently of anaemia, reflecting the growing awareness of the condition as a significant barrier in the management of heart failure.

Iron appears to have a detrimental effect on the survival of certain types of ovarian cancer cells, a new scientific study finds. Researchers studied the effect of ferric ammonium citrate (FAC) on ovarian cancers cells containing mutations in the Ras gene. They found that these cells were more sensitive to FAC than cancer cells without these mutations, exhibiting a marked decrease in growth and cell survival.

Single-dose ferric carboxymaltose has similar safety and tolerability compared with current treatments for iron deficiency anaemia in patients with chronic kidney disease (CKD), new data shows. The treatment could be suitable for outpatient use, potentially decreasing the need for patient clinic visits and venipuncture.

High dose intravenous ferric carboxymaltose does not alter levels of inflammatory and endothelial markers in patients with pre-dialysis chronic renal failure and iron deficiency anaemia, according to a new report. The study provides initial evidence addressing concerns regarding the pro-inflammatory properties of intravenous iron.

The European Renal Best Practice (ERBP) group has published a statement in response to some of the recommendations laid out in the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for anaemia management in chronic kidney disease1. The group felt that some of the KDIGO recommendations were ‘soft’ and that the global guidelines needed to be adapted for implementation at a European level.

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